What is lidocaine?

Lidocaine is a local anesthetic, also known as sirocaine, which has replaced procaine in recent years and is widely used for local infiltration anesthesia in cosmetic surgery. It blocks nerve excitation and conduction by inhibiting sodium ion channels in nerve cell membranes. Its lipid solubility and protein binding rate are higher than those of procaine, with strong cell penetrating ability, fast onset, long action time, and an action intensity four times that of procaine.

Clinical applications include infiltration anesthesia, epidural anesthesia, surface anesthesia (including mucosal anesthesia during thoracoscopy or abdominal surgery), and nerve conduction block. In order to prolong the duration of anesthesia and reduce side effects such as lidocaine poisoning, adrenaline can be added to the anesthetic.

Lidocaine can also be used to treat ventricular premature beats, ventricular tachycardia, digitalis poisoning, ventricular arrhythmias caused by cardiac surgery and catheterization after acute myocardial infarction, including ventricular premature beats, ventricular tachycardia, and ventricular fibrillation.Secondly, it is also used for patients with persistent epilepsy who are ineffective with other anticonvulsants and for local or spinal anesthesia. But it is usually ineffective for supraventricular arrhythmias.

Research progress on perioperative intravenous infusion of lidocaine infusion

Perioperative use of opioid drugs can provoke multiple adverse reactions, which promote in-depth research on non-opioid analgesic drugs. Lidocaine is one of the most efficacious non-opioid analgesic drugs. Perioperative administration of lidocaine can reduce the intraoperative dosage of opioid drugs, relieve postoperative pain, accelerate postoperative recovery of gastrointestinal function, shorten the length of hospital stay and promote postoperative rehabilitation.

Clinical application of intravenous lidocaine during perioperative period

1.Reduce stress response during anesthesia surgery

2.reduce the intraoperative dosage of opioid drugs, relieve postoperative pain

3.Promote the recovery of gastrointestinal function, reduce the incidence of postoperative nausea and vomiting (PONV) and postoperative cognitive impairment (POCD), and shorten hospital stay

4.Other functions

In addition to the above effects, lidocaine also has the effects of alleviating injection pain of propofol, inhibiting cough response after extubation, and alleviating myocardial damage.


Post time: May-17-2023